Motorists are advised that the A1 has now been closed in both directions following the single vehicle road traffic collision.
It happened at Sheepsbridge and the closure is to allow police to investigate the circumstances of the collision.
The male driver of the car has been taken to hospital where his condition is described as serious.
Diversions are in place.
Delays are expected.
There are no further details at this stage.
This story will be automatically updated.